May ↑plasma concentrations of lithium & digoxin. Increased neprhrotoxicity when used with diuretics or ciclosporin. Monitor serum K+ when used with potassium sparing diuretics & ACE inhibitors. May enhance activity of anticoagulants. May enhance activity of anticoagulants/ may ↑risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDS.increased risk of convulsion with quinolones.