Children≤12 yr should not receive >5 doses/24 hr without notifying physician or other health care professional
Hypersensitivity to acetaminophen or any component of the formulation;
Severe hepatic impairment or severe active liver disease (IV).
Use Cautiously in:
GI: hepatic failure , hepatotoxicity(overdose).
GU: renal failure (high doses/chronic use).
Hemat: neutropenia, pancytopenia, leukopenia .
Derm: rash, urticaria .
Barbiturates, carbamazepine, hydantoins, sulfinpyrazone
May decrease therapeutic effect of acetaminophen; concomitant long-term use may increase risk of hepatotoxicity. At usual therapeutic doses, no special precautions are needed.
As an antidote, charcoal can decrease the absorption of acetaminophen when given as soon as possible after overdosage.
Long-term excessive use of alcohol may increase risk of hepatotoxicity. Use with caution in patients with a history of chronic alcohol ingestion.
Acetaminophen may reduce plasma concentration. If an interaction is suspected, adjust the lamotrigine dose accordingly.
Possible increased risk of bleeding, especially with dosages of more than 325 mg/day. More frequent assessment of INR is warranted. Adjust the warfarin dose as needed.
Therapeutic Classification: antipyretics, nonopioid analgesics
Absorption: Well absorbed following oral administration. Rectal absorption is variable.
Distribution: Widely distributed. Crosses the placenta; enters breast milk in low concentrations.
Metabolism/Excretion: 85–95% metabolized by the liver. Metabolites may be toxic in overdose situation. Metabolites excreted by the kidneys.
Half-life: Neonates: 2–5 hr. Adults: 1–3 hr.
Depends on dose
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