As adjuvant therapy for patients with abnormal, viscid, or inspissated mucous secretions in such conditions as chronic bronchopulmonary disease (chronic emphysema, emphysema with bronchitis, chronic asthmatic bronchitis, tuberculosis, bronchiectasis and primary amyloidosis of the lung), acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis), pulmonary complications of cystic fibrosis, tracheostomy care, pulmonary complications associated with surgery, during anesthesia, posttraumatic chest conditions, atelectasis caused by mucous obstruction, and diagnostic bronchial studies (eg, bronchograms, bronchospirometry, bronchial wedge catheterization) (inhalation); prevention or lessening of liver damage after potentially toxic quantity of acetaminophen (oral or IV).
Ophthalmic preparation for dry eyes; enema for bowel obstruction; prevention of radiocontrast-induced nephrotoxicity.
PO (Adults and Children): 140 mg/kg initially, followed by 70 mg/kg q 4 hr for 17 additional doses.
IV (Adults and Children): Loading dose —150 mg/kg over 15 min initially followed by First maintenance dose —50 mg/kg over 4 hr, then second maintenance dose — 100 mg/kg over 16 hr.
Inhaln (Adults and Children): Nebulization via face mask —3–5 ml of 20% solution or 6–10 ml of the 10% solution 3–4 times daily (range — 1–10 ml of 20% solution or 2–20 ml of 10% solution q 2–6 hr); nebulization via tent or croupette —volume of 10–20% solution required to maintain heavy mist; direct instillation —1–2 ml of 10–20% solution q 1–4 hr; intratracheal instillation via tracheostomy —1–2 ml of 10–20% solution q 1–4 hr (up to 2–5 ml of 20% solution via tracheal catheter into particular segments of the bronchopulmonary tree).
Unlabeled Use (prevention of radiocontrast-induced renal dysfunction)
PO (Adults): 600 mg twice daily for 2 days, beginning the day before the procedure.
Decreases thickness of mucous secretions in lung; protects the liver by maintaining or restoring glutathione levels or by acting as an alternate substrate for conjugation with, and thus detoxification of, the acetaminophen reactive metabolite.