INTRAVENOUS: Severe initial episodes of genital herpes in nonimmunosuppressed patients. Mucosal or cutaneous herpes simplex infections or herpes zoster infections (shingles) in immunosuppressed patients. Herpes simplex encephalitis .
Topical: Cream —Recurrent herpes labialis (cold sores). Ointment —Treatment of limited non–life-threatening herpes simplex infections in immunocompromised patients (systemic treatment is preferred).