Contraindicated in pregnancy
Contraindicated in lactation
Since mucolytics may disrupt the gastric mucosal barrier, bromhexine should be used with caution in patients with a history of gastric ulceration.
Clearance of bromhexine or its metabolites may be reduced in patients with severe hepatic or renal impairment.
History of peptic ulceration; asthama patients. Severe hepatic or renal impairment