Adults: IM/IV Moderate to severe infections: 500 mg to 1 g every 6 to 8 h. Mild infections: 250 to 500 mg every 8 h. Severe, life-threatening infections: 1 to 1.5 g every 6 h.
Children older than 1 month of age: IM/IV Mild to moderate infections: 25 to 50 mg/kg (10 to 20 mg/lb) daily divided into 3 or 4 equal doses. Severe infections: 100 mg/kg (45 mg/lb).
Acute Uncomplicated UTIs
Adults: IM/IV 1 g every 12 h.
Adults: IM/IV 500 mg every 12 h.
Adults: IM/IV 1 g administered ½ to 1 h prior to start of surgery. Operative procedures of 2 h or more: 500 mg to 1 g during surgery. Postoperatively: 500 mg to 1 g every 6 to 8 h for 24 h.
Inhibition of bacterial cell wall synthesis.
Hypersensitivity to cephalosporins.
Use Cautiously in:
CNS: Hyperactivity; hypertonia.
GI: Abdominal pain; anal pruritus; anorexia; colitis; diarrhea; nausea; oral candidiasis; pseudomembranous colitis; stomach cramps; vomiting.
GU: Genital pruritus (including genital moniliasis, vaginitis, vulvar pruritus).
HEMA/LYMPH: Agranulocytosis; aplastic anemia; hemolytic anemia; hemorrhage; leukopenia; neutropenia; pancytopenia; thrombocythemia; thrombocytopenia.
LABTESTABS: Increased alkaline phosphatase, AST, or ALT; elevated bilirubin; elevated LDH; increased creatine; prolonged prothrombin time.
LOCAL: Pain; phlebitis.
RENAL: Increased BUN and creatinine; renal function impairment; toxic nephropathy.
OTHER: Allergy (including anaphylaxis, drug fever, eosinophilia, erythema multiforme, itching, skin rash, serum sickness–like reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria); superinfection.
Aminoglycosides (eg, gentamicin)
Increased risk of nephrotoxicity.
Cefazolin renal tubular secretion may be decreased, increasing and prolonging blood levels.
Anticoagulant effect may be increased.
Therapeutic Classification: anti-infectives
Pharmacologic Classification: first generation cephalosporins
Absorption: Well absorbed after IM administration.
Distribution: Widely distributed. Penetrates bone and synovial fluid well. Crosses the placenta and enters breast milk in low concentrations. Minimal CSF penetration .
Protein Binding: 74 — 86%.
Metabolism/Excretion: Excreted almost entirely unchanged by the kidneys.
Half-life: Neonates: 3–5 hrs; Adults: 90–150 min (increased in renal impairment).
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