Absorption: Cefpodoxime proxetil is a prodrug that is converted to cefpodoxim (the active component) in GI tract during absorption; 50% absorbed after oral administration; absorption of tablets increased with food.
Distribution: Widely distributed. Crosses the placenta; enters breast milk.
Metabolism/Excretion: 29–33% excreted unchanged in urine.
Half-life: 2–3 hr (increased in renal impairment).