Adults: PO 1 to 4 g/day in divided doses (max, 4 g/day).
Children: PO 25 to 50 mg/kg/day in divided doses.
Hypersensitivity to cephalosporins.
Use Cautiously in:
CNS: Agitation, confusion, dizziness, fatigue, hallucinations, headache.
GI: Anorexia; abdominal pain or cramps; colitis, including pseudomembranous colitis; diarrhea; dyspepsia; flatulence; gastritis; nausea; vomiting.
GU: Genital moniliasis, genital pruritus, reversible interstitial nephritis, vaginitis and vaginal discharge.
HEMA: Eosinophilia, hemolytic anemia, neutropenia, thrombocytopenia.
HEPA: Cholestatic jaundice, elevated AST and ALT, hepatitis.
MUSC: Arthralgia, arthritis, joint disorder.
OTHER: Anal pruritus; anaphylaxis; candidal overgrowth; hypersensitivity, including rash, Stevens-Johnson syndrome, angioedema, erythema multiforme, toxic epidermal necrolysis, and urticaria.
May increase metformin plasma Cmax and AUC.
Inhibition of renal excretion of cephalexin.
Therapeutic Classification: anti-infectives
Pharmacologic Classification: first generation cephalosporins
Absorption: Cephalexin is rapidly absorbed. Cmax is about 9 to 32 mcg/mL (250 mg to 1 g doses). Tmax is 1 h.
Distribution: Cephalexin is 10% protein bound.
Excretion: More than 90% is excreted unchanged in the urine within 8 h. The half-life is 50 to 80 min.
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