Adults:PO Initial dose is 600 mg, then 300 mg 6 h later and 300 mg every day for 2 days.
Children:PO Initial dose is 10 mg/kg, then 5 mg/kg 6 h later and 5 mg/kg every day for 2 days.
Adults:PO 300 mg base.
Children: 5 mg/kg/dose (max 300 mg base) weekly. Begin 1 to 2 wk prior to exposure and continue for 4 wk after leaving endemic area. If suppressive therapy is not begun prior to exposure, double initial loading dose and give in 2 divided doses 6 h apart.
Adults:PO 600 mg base/day for 2 days, then 300 mg base/day for 2 to 3 wk.