Treatment of serious infections caused by susceptible strains of anaerobic bacteria staphylococci, streptococci, and pneumococci in conditions such as lower respiratory tract infections, skin and skin structure infections, gynecological infections, intra-abdominal infections, septicemia, and bone and joint infections (PO/IV/IM). Treatment of acne vulgaris (topical use). Treatment of bacterial vaginosis (vaginal use) in nonpregnant women and second or third trimester pregnant women .
Alternative to sulfonamides in combination with pyrimethamine in the acute treatment of CNS toxoplasmosis in AIDS patients; treatment of Chlamydia trachomatis infections in women; alternative to metronidazole in the treatment of bacterial vaginosis caused by Gardnerella vaginalis .
PO (Adults): Most infections — 150–450 mg q 6 hr. P. carinii pneumonia —1200–1800 mg/day in divided doses with 15–30 mg primaquine/day (unlabeled). CNS toxoplasmosis —1200–2400 mg/day in divided doses with pyrimethamine 50–100 mg/day (unlabeled); Bacterial endocarditis prophylaxis —600 mg 1 hr before procedure .
PO (Children >1 mo): 10–30 mg/kg/day divided q 6–8 hr; maximum dose 1.8 g/day. Bacterial endocarditis prophylaxis —20 mg/kg 1 hr before procedure.
IM, IV (Adults): Most infections —300–600 mg q 6–8 hr or 900 mg q 8 hr (up to 4.8 g/day IV has been used; single IM doses of >600 mg are not recommended). P. carinii pneumonia —2400–2700 mg/day in divided doses with primaquine (unlabeled). Toxoplasmosis —1200–4800 mg/day in divided doses with pyrimethamine. Bacterial endocarditis prophylaxis-600 mg 30 min before procedure.
IM, IV (Children >1 mo): 25–40 mg/kg/day divided q 6–8 hr; maximum dose: 4.8 g/day. Bacterial endocarditis prophylaxis — 20 mg/kg 30 min before procedure; maximum dose: 600 mg.
IM, IV (Infants <1 mo and < 2 kg): 5 mg/kg q 8–12 hr 2 kg — 20–30 mg/kg/day divided q 6–8 hr.
Vag (Adults and Adolescents): Cleocin, Clindamax —1 applicatorful (5 g) q hs for 3 or 7 days (7 days in pregnant patients); Clindesse —one applicatorful (5 g) single dose; or 1 suppository (100 mg) at bedtime for 3 nights.
Topical (Adults and Adolescents): Solution — 1% solution/suspension applied twice daily (range 1–4 times daily). Foam, gel — 1% foam or gel applied once daily.