Treatment of anxiety oral: short term – anxiety disorders adjunctive therapy in the management of epilepsy :
Adult; 20-30 mg as a single dose at night or as daily divided doses, increased to 60mg/
day in severe conditions. Child:3-12 yr: 125mcg/kg bid increased every 5 days. Usual maintenance dose:
250 mcg/kg bid. Max:500 mcg/kg bid.Elderly :or debilitated patients:10-20mg daily.
To one or more specific Clobazam binds GABA receptors at several sites within the CNS
including the limbic system and reticular formation.
Increased permeability of neuronal membrane to chloride ions results in GABA;s inhibitory effect leading to hyperpolarisation and stabilisation.
Anorexia, Constipation, nausea;dizziness, fine tremorsl worsening of respiratiory symptoms in predisposed individuals;ataxia, drowsiness, headache, confusionl loss of libido, motor dysfunction;depende nce;visual disturbances and weight gain.
After oral administration, clobazam is rapidly and virtually completely absorbed, with plasma peak concentrations in 1–4 h. It is highly lipid soluble and 90% protein bound. Clobazam is extensively metabolized in the liver to several metabolites. The half-life of the parent compound is 18 h. N-desmethyl-clobazam, the main active metabolite, attains maximal plasma concentration after 24–72 h. Its elimination half-life is approximately 50 h