| • | Induces ovulation in anovulatory women who desire pregnancy. Requires intact anterior pituitary, thyroid, and adrenal function. |
Unlabeled Uses:
| • | Male infertility due to oligospermia. |
Ovulatory Failure (Females) /Skyscape/Desktop/DrDrugs/0/tn0.gif){kind=small}
| • | PO (Adults): 50 mg/day for 5 days (begin on or about 5th day of cycle); if ovulation does not occur, a second course of 100 mg/day for 5 days may be given 30 days after the initial course. A maximum of 3 courses may be administered. Increasing dose above 100 mg/day for 5 days is not recommended . |
Male Infertility
| • | PO (Adults): 25 mg/day for 25 days with 5 days rest or 100 mg every Monday, Wednesday, and Friday . |
| • | Stimulates release of pituitary gonadotropins, follicle-stimulating hormone, and luteinizing hormone, resulting in ovulation and the development of the corpus luteum. |
Therapeutic Effects:
| • | Induction of ovulation. |
Contraindicated in:
| • | Liver disease or history of liver dysfunction. | |
| • | Enlargement or development of ovarian cysts (not due to polycystic ovarian syndrome). | |
| • | Pregnancy. | |
| • | Uncontrolled thyroid or adrenal dysfunction. | |
| • | Pituitary tumor. | |
| • | Abnormal uterine bleeding of unknown origin. |
Use Cautiously in:
| • | Endometriosis. | |
| • | Fibroids. | |
| • | Known sensitivity to pituitary gonadotropins (e.g. polycystic ovary syndrome). |
CNS: headache .
EENT: blurred vision, floaters, photophobia, scotomata , phosphenes.
CV: hot flashes .
GI: abdominal pain , bloating, distention , nausea, vomiting , /Skyscape/Desktop/DrDrugs/6/tn0.gif){kind=small}
liver enzymes.
Endo: ovarian cyst formation , ovarian enlargement , breast discomfort, multiple births, intermenstrual spotting , abnormal menstrual flow.
Metab: weight gain.
Drug-Drug:
| • | None significant. |
Therapeutic Classification: ovulation inducer
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Metabolism/Excretion: Metabolized by the liver, with enterohepatic recirculation. Excreted in feces.
Half-life: 5–7 days.
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| ORAL | 5-14 DAYS | UNKNOWN | UNKNOWN |
