• PO (Adults ): 250–500 mg q 6 hr.
• PO (Children > 1 mo ): 50–100 mg/kg/day divided q 6 hr up to a maximum of 4 g/day.
Use Cautiously in:
CNS: seizures .
GI: diarrhea, epigastric distress, nausea, vomiting , pseudomembranous colitis.
GU: interstitial nephritis .
Derm: rash , urticaria.
Hemat: eosinophilia, leukopenia .
Misc: allergic reactions including anaphylaxis and serum sickness , superinfection.
Therapeutic Classification: anti-infectives
Pharmacologic Classification: penicillinase resistant penicillins
Absorption: Moderately absorbed (50%) following oral administration.
Distribution: Widely distributed; penetration into CSF is minimal but sufficient in the presence of inflamed meninges; cross the placenta and enter breast milk.
Metabolism/Excretion: Some metabolism by the liver (9–22%) and some renal excretion of unchanged drug (30–45%).
Half-life: 0.5–1.1 hr (increased in severe hepatic, renal dysfunction and in neonates).
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