Oral Filariasis; loiasis; toxocariasis
Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections. Oral Prophylaxis of loiasis
Adult: 300 mg wkly.
is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine’s activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine’s mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration.