TiD, gradually increased Adult: Initially, 25 mg to 50 mg tid if necessary, alternatively as a single dose at night. Up to 225 mg/ day may be used in severe depression.
Elderly: Initially, 50-75 mg daily.
sexual dysfunction, Cholestatic jaundice, exacerbation of psychotic manifestation, cardiac arrhythmias, hypotension, dry mouth, constipation, disturbance of accommodation, tachycardia, postural hypotension, drowsiness,tremors and skin rash.
Withdrawal symptoms with abrupt cessation:
Insomnia, irritability and excessive sweating.
Potentially Fatal: Bone marrow depression, cardiac arrhythmias and agranulocytosis, reports of ventricular fibrillation and renal failure
Barbiturates reduceantidepressant effect of dosulepin. Raised serum concentrations with methylphenidate. Cigarette smoking enhances metabolism. Increased risk of ventricular arrhythmias when used with drugs that
prolong QT interval. Potentially Fatal: Should not be given concurrently or within 14 days of stopping MAOIs. Potentiates catecholamines, sympathomimetics, narcotics and alcohol. Reduces hypotensive activity of bethanidine, guanethidine.