Plasma levels may be elevated by erythromycin, increasing the pharmacologic effects and risk of toxicity (eg, rhabdomyolysis with lovastatin or simvastatin).
Antagonism may occur with topical erythromycin; coadministration is not recommended.
May cause increased digoxin levels.
Ergot toxicity may occur.
Administer capsules containing enteric-coated pellets and film-coated tablets at least 2 h before or after a meal to achieve optimal blood levels. Erythromycin was 28% bioavailable following administration of the polymer-coated particle formulation with a high-fat meal.
Plasma concentrations may be reduced when administered with food. Optimum levels are achieved when administered at least 1 h before or 2 h after meals. High blood levels were achieved when administered immediately before a meal.
Erythromycin estolate and ethylsuccinate
Food may enhance the absorption; however, may be given without regard to meals.
May inhibit erythromycin metabolism, increasing plasma levels and adverse reactions.