Absorption: At least 49% absorbed. Tmax is 1 to 1.5 h. Cmax is approximately 1.6 mcg/mL.
Distribution: Vd is 50 L. Plasma protein binding is approximately 99.2%, primarily to albumin.
Metabolism: Extensively metabolized by both conjugation via uridine diphosphate glucuronosyltransferase enzymes and oxidation via CYP enzymes, including CYP1A2, 2C8, and 2C9, as well as non-P450 isozymes.
Excretion: Mean terminal elimination half-life is approximately 5 to 8 h. Approximately 49% is recovered in the urine and approximately 45% is recovered in the feces.