Absorption: Tmax is 2.6 h; Cmax is 131 ng/mL (tablets). Tmax is 2 h; Cmax is 88 ng/mL (orally disintegrating tablet [ODT]). Tmax is 1 h; Cmax is 118 ng/mL (suspension). Administration with a high-fat meal decreased AUC and Cmax by 21% and 20%, respectively (tablets), 40% and 60%, respectively (ODT), and 30% to 47%, respectively (suspension).
Distribution: 60% to 70% is bound to plasma proteins. The drug does not cross the blood-brain barrier.
Metabolism/Excretion: 80% excreted in urine, 11% excreted in feces.
Half-life:14.4 hr (increased in renal impairment).