Depression Use parenterally only in patients who are not able or not willing to take oral medication. Give via IM route. Do not administer IV. Up to 100 mg/day in divided doses may be given IM. Switch to oral as soon as possible.
Adults:PO 100 to 300 mg/day, in divided doses or once daily at bedtime.
Elderly & Adolescents:PO 30 to 40 mg/day; may increase up to 100 mg/day.
Children:PO 1.5 mg/kg/day in divided doses; up to maximum of 5 mg/kg/day.
Childhood Enuresis (6 yr):PO 25 mg/day given 1 h before bedtime; if response unsatisfactory after 1 wk, may increase to 50 mg in children younger than 12 yr of age. Children older than 12 yr of age may receive 75 mg/night. Do not exceed 2.5 mg/kg/day.
Hypersensitivity to any tricyclic antidepressant. Generally not to be given in combination with or within 14 days of treatment with MAO inhibitor or during acute recovery phase of MI; cross-sensitivity may occur among the dibenzazepines.