Insulin aspart, insulin aspart mix, insulin lispro, insulin lispro mix
Treatment of patients with diabetes mellitus for the control of hyperglycemia.
Insulin detemir, insulin glargine
Treatment of adults and children with type 1 diabetes or adults with type 2 diabetes mellitus who require long-acting insulin for control of hyperglycemia.
Treatment of adults and children with diabetes mellitus for the control of hyperglycemia.
During episodes of hypoglycemia (insulin aspart, insulin glulisine, insulin lispro, insulin lispro mix); hypersensitivity to any component.
Use Cautiously in:
Endo: hypoglycemia .
Local: lipodystrophy, pruritis , erythema, swelling.
Misc: allergic reactions including anaphylaxis.
ACE inhibitors, disopyramide, fenfluramine, fibrates, fluoxetine, MAOIs, octreotide, oral hypoglycemic agents, pentoxifylline, propoxyphene, salicylates, sulfa antibiotics
May increase hypoglycemic effects of insulin.
Alcohol, beta-blockers, clonidine, lithium salts
May potentiate or weaken the blood glucose–lowering effects of insulin.
Atypical antipsychotics, corticosteroids, danazol, diazoxide, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, protease inhibitors, somatropin, sympathomimetics, thyroid hormone
May decrease hypoglycemic effects of insulin.
Beta-blockers, clonidine, guanethidine, reserpine
Signs of hypoglycemia may be reduced or absent.
May cause hypoglycemia, which may be followed by hyperglycemia.
Therapeutic Classification: antidiabetics, hormones
Pharmacologic Classification: pancreatics
Absorption: Rapid acting.
Distribution: Identical to endogenous insulin.
Metabolism/Excretion: Metabolized by liver, spleen, kidney, and muscle.
Half-life: Approximately 60–90 min.
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