Relapsing forms in multiple sclerosis.
IM (Adults): 30 mcg once weekly.
CNS: seizures , depression, dizziness, fatigue, headache , drowsiness, incoordination , rigors, suicidal ideation .
EENT: sinusitis, vision abnormalities .
Resp: upper respiratory tract infection.
CV: chest pain, heart failure .
GI: abdominal pain, nausea , autoimmune hepatitis, dry mouth , elevated liver function studies .
GU: urinary tract infection, urinary incontinence , polyuria.
Derm: alopecia, rash .
Endo: hyperthyroidism , hypothyroidism, spontaneous abortion.
Hemat: neutropenia, anemia , thrombocytopenia.
Local: injection-site reactions , injection site necrosis.
MS: myalgia , arthralgia, back pain , muscle spasm.
Misc: allergic reactions including anaphylaxis, chills, fever , flu-like symptoms , pain.
Because of potential to cause neutropenia and lymphopenia, monitor patients during concomitant therapy.
Therapeutic Classification: anti-multiple sclerosis agents , immune modifiers
Pharmacologic Classification: interferons
Absorption: — 50% absorbed following subcut administration.
Half-life: 69 hr (subcutaneous), 10 hr (IM).
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