Preparation for Thyroidectomy PO (Adults and Children): Strong iodine solution — 3–5 drops (0.1–0.3 ml) 3 times daily for 10 days prior to surgery. Potassium iodide saturated solution (SSKI) — 1–5 drops (50–250 mg) 3 times daily for 10 days prior to surgery.
Hyperthyroidism PO (Adults and Children): Strong iodine solution — 1 ml in water 3 times daily. Potassium iodide saturated solution (SSKI) — 6–10 drops (300–500 mg) 3 times daily. PO (Infants <1 yr): 3–5 drops (150–250 mg) 3 times daily.
Radiation Protectant to Radioactive Isotopes of Iodine PO (Adults): Pima —195 mg once daily for 10 days (start 24 hr prior to exposure (continue until risk of exposure has passed or other measures have been implemented). PO (Children >1 yr): 130 mg once daily for 10 days (start 24 hr prior to exposure). PO (Infants <1 yr): 65 mg once daily for 10 days (start 24 hr prior to exposure).
Reduction of Thyroid Cancer after Nuclear Accident
PO (Adults and Children >68 kg, including pregnant/lactating women): Iosat, ThyroSafe, ThyroShield-130 mg once daily (continue until risk of exposure has passed or other measures have been implemented).
PO (Children 3–18 yr): 65 mg once daily.
PO (Children 1 mo-3 yr): 32.5 mg once daily.
PO (Infants <1 mo): 16.25 mg once daily.
Rapidly inhibits the release and synthesis of thyroid hormones.
↓ s the vascularity of the thyroid gland.
↓ s thyroidal uptake of radioactive iodine following radiation emergencies or administration of radioactive isotopes of iodine.
Iodine is a necessary component of thyroid hormone. Therapeutic Effects:
Control of hyperthyroidism.↓ d bleeding during thyroid surgery.
↓ d incidence of thyroid cancer following radiation emergencies.
OB: Pedi: Pregnancy or lactation (although iodine is required during pregnancy, excess amounts may cause thyroid abnormalities/goiter in the newborn; excess use during lactation may cause skin rash or thyroid suppression in the infant).
Absorption: Converted in the GI tract and enters the circulation as iodine; also absorbed through skin and lungs; may also be obtained via recycling of iodothyronines. Distribution: Concentrates in the thyroid gland and muscle; also found in skin, skeleton, breasts, and hair. Readily crosses the placenta; enters breast milk. Metabolism/Excretion: Taken up by the thyroid gland, then eliminated via kidneys, liver, skin, lungs, and intestines.