Treatment of hypertension; nephropathy in type 2 diabetes.
Adults: PO Start with 150 mg every day; then titrate to 300 mg every day as necessary.
Children (13 to 16 yr of age): PO Start with 150 mg every day; then titrate patients requiring a further reduction in BP to 300 mg every day.
Children (6 to 12 yr of age): PO Start with 75 mg every day; then titrate patients requiring a further reduction in BP to 150 mg every day.
Nephropathy in Type 2 Diabetes
Adults: PO Titrate dose to 300 mg every day.
Volume- and Salt-Depleted Patients PO Start with 75 mg.
Use Cautiously in:
CNS: anxiety, dizziness , fatigue, headache.
CV: chest pain, edema, hypotension, tachycardia.
GI: abdominal pain , diarrhea, dyspepsia, nausea , vomiting.
GU: impaired renal function.
F and E: hyperkalemia .
Plasma concentrations my be increased by irbesartan, resulting in an increase in the pharmacologic and adverse effects of lithium.
Therapeutic Classification: antihypertensives
Pharmacologic Classification: angiotensin ii receptor antagonists
Absorption: 60–80% absorbed following oral administration.
Distribution: Crosses the placenta.
Protein Binding: 90%.
Metabolism/Excretion: Some hepatic metabolism; 20% excreted in urine, 80% in feces.
Half-life: 11–15 hr.
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