Adults: PO 900 to 1800 mg/day in 2 to 4 divided doses. Give regular capsules 3 or 4 times daily; slow-release tablets 2 or 3 times daily. Max dose, 2,400 mg/day.
Children 12 yr of age and older: 15 to 20 mg/kg/day in 2 to 3 divided doses.
Store at room temperature. Protect capsules from moisture.
Use Cautiously in:
CV: Arrhythmias; hypotension; bradycardia; peripheral circulatory collapse.
CNS: Tremor; muscle hyperirritability; headache; fatigue; ataxia; dizziness; psychomotor retardation; confusion; dystonia; hallucinations; blackouts; seizures; pseudotumor cerebri; drowsiness; poor memory and intellectual function; muscular weakness; slurred speech.
DERM: Drying or thinning hair; dry skin; pruritus; exacerbation of psoriasis; acne.
EENT: Blurred vision; tinnitus.
GI: Anorexia; nausea; vomiting; diarrhea; sialorrhea; dry mouth; parotitis.
GU: Urinary urgency; stress incontinence; polyuria; albuminuria; sexual dysfunction; symptoms of nephrogenic diabetes; decreased CrCl.
HEMA: Leukocytosis; leukemia.
METAB: Hypothyroidism; hypercalcemia; hyperparathyroidism; hyponatremia; dehydration; weight gain.
OTHER: Taste distortion; thirst; fever; swollen joints.
Acetazolamide, osmotic diuretics, theophyllines, urinary alkalinizers
Increased renal excretion of lithium.
ACE inhibitors, fluoxetine, loop diuretics, NSAIDs, thiazide diuretics
Increased lithium serum levels.
Carbamazepine, haloperidol, methyldopa
Increased neurotoxic effects despite therapeutic serum levels and normal dosage range.
Increased risk of hypothyroidism.
Neuromuscular blocking agents, tricyclic antidepressants
Increased pharmacological effects of additive drug.
Neurotoxicity, decreased phenothiazine concentrations, or increased lithium concentrations may occur.
Reductions in lithium levels and lithium toxicity have occurred.
Antipsychotic agent , Antidepressent
Absorption: Completely absorbed after oral administration.
Distribution: Widely distributed into many tissues and fluids; CSF levels are 50% of plasma levels. Crosses the placenta; enters breast milk.
Metabolism/Excretion: Excreted almost entirely unchanged by the kidneys.
Half-life: 20–27 hr.
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