Mebeverine is a drug used to alleviate some of the symptoms of irritable bowel syndrome. It works by relaxing the muscles in and around the gut.
Irritable bowel syndrome, Gastrointestinal tract spasm Adult: As hydrochloride: 135 mg tid or 100 mg tid. Modified-release preparation: 200 mg bid. As embonate: 150 mg tid. Child: As hydrochloride: 3-4 yr: 25 mg; 4-8 yr: 50 mg; 8-10 yr: 100 mg; >10 yr: 135-150 mg. All doses may be given tid. Modified-release preparation: Not recommended.
Should be taken with food. (Take immediately before or during meals.)
Mebeverine is an antispasmodic agent which exerts direct action on the GI smooth muscle.
After taking Colofac Tablets 135 mg, very rarely do, people taking this medicine may develop allergic reactions. These may include inflamed or reddened skin, itching or skin rashes.
Severe hepatic or renal impairment; cardiac disorders e.g. heart block; porphyria. May impair ability to drive or operate machinery. Pregnancy and lactation.
GI disturbances, dizziness, headache, insomnia, anorexia, decreased heart rate, hypersensitivity reactions.
Absorption: Rapidly absorbed from the GI tract (oral); peak plasma concentrations within 1-3 hr.
Distribution: Protein-binding: 75% to albumin.
Metabolism:Hydrolysed completely in the liver to veratric acid and mebeverine alcohol.
Excretion:Via urine (as metabolites).
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