Amoebic Dysentery Adult: 1.5 as a single daily dose for three days. Alternatively for patients > 60 kg: 1 g bid for three days.
Child: 40 mg/kg daily. Giardiasis Adult: 1-1.5g as a single dose for 1-2 days. Child: 30-40 mg/kg daily. Trichomoniasis Adult: 1.5g as a single dose or 0.5 g bid for 5 days. Treat sexual partners concominantly. Amoebiasis Adult: 0.5 g bid for 5-10 days. Child: 25 mg/kg as a single dose for 5-10 days. Intravenous Severe amoebic dysentery & amoebic liver abscess Adult: Initially 0.5-1 g infusion followed by 0.5 g every 12 hours for 3-6 days. Child: 20-30 mg/kg body weight daily. Anaerobic bacterial infections Adult: Initially 0.5-1 g followed by 1 g daily as a single dose or in divided doses for 5.10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hours orally as soon as possible. Child: 10 mg/kg every 12 hours for 5-10 days. Prevention of postoperative anaerobic bacterial infections Adult: 1 g by IV about 30 minutes before surgery.
Hypersensitivity cross sensitivity with other imidazoles may occur.First trimester of pregnancy.
Lactation. Use Cautiously In: CNS pathology.
History of blood dyscrasia.
Hemodialysis (removes significant amount of tinidazole; supplement post-dialysis with additional 50% of dose).
Unrecognized candidiasis (requires concurrent antifungal therapy).
Children younger than 3 yr (safety not established).
↑ risk of bleeding with warfarin.
Disulfiram-like reaction may occur with alcohol or propylene glycol; disulfiram should be avoided for at least 2 weeks before tinidazole.
May↑ level of lithium, cyclosporine, tacrolimus, fluorouracil, and intravenous fosphenytoin (observe/monitor for toxicity if administered concurrently).
Drugs that induce to CYP450 liver enzyme system (phenobarbital, rifampin, phenytoin or fosphenytoin) may ↓ levels and effectiveness.
Drugs that inhibit to CYP450 liver enzyme system (cimetidine or ketoconazole) may ↑ levels.
Oxytetracycline may ↓ effectiveness.
Absorption is ↓ by cholestyramine; separate dosing.