Oral Prophylaxis of migraine, Prophylaxis of cluster headache Adult: 1.5 mg/day either in 3 divided doses or as a single dose at night.
Gradual ↑of 0.5 mg helps to avoid drowsiness. Max dose: 4.5 mg/day and 3 mg/dose.
Child: >2 yr: Up to 1.5 mg daily in divided doses. Max dose: 1 mg/dose.
Renal impairment: Dose reduction may be needed.
Absorption: Well absorbed. Distribution: About 90% bound to plasma proteins. peak plasma concentrations occur about 5 hr after a single oral dose. Metabolism: Extensively metabolised. Excretion: About half of a dose is excreted in the urine, mainly as metabolites.