Both prevention and treatment of premature labor in pregnancy of greater or equal to 20 wk duration.
IV (Adults): 50–100 mcg/min, increased q 10 min by 50 mcg/min until desired response is obtained or maternal heart rate reaches 130 bpm, followed by maintenance infusion at 150–350 mcg/min.
• Hypersensitivity.• Cardiovascular disease or uncontrolled hypertension. • Uncontrolled hyperthyroidism. • Pheochromocytoma. • Chorioamnionitis. • Hypovolemia. • Pulmonary hypertension. • Eclampsia. • Intrauterine fetal death or nonreassuring fetal status . • Pregnancy <20 weeks.
Use Cautiously in:
CNS: headache, anxiety , nervousness.
CV: pulmonary edema, angina , hypotension, tachycardia (maternal and fetal).
GI: nausea, vomiting , drug-induced hepatitis.
Hemat: agranulocytosis , leukopenia.
Therapeutic Classification: tocolytic
Pharmacologic Classification: adrenergics
Absorption: IV administration results in complete bioavailability.
Distribution: Crosses the placenta in significant amounts; maternal and fetal concentrations may be equal.
Metabolism/Excretion: Metabolized by the liver to inactive compounds; also metabolized by the fetus.
Half-life: 1.7–2.6 hr.
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