Severe renal impairment, especially in patients on dialysis.
Moderate hepatic impairment.
Pregnancy, lactation, or children <18 yr (safety not established).
Exercise Extreme Caution in:
Cardiovascular risk factors (hypertension, hypercholesterolemia, cigarette smoking, obesity, diabetes, strong family history, menopausal women or men >40 yr); use only if cardiovascular status has been evaluated and determined to be safe and first dose is administered under supervision.