Adults:PO Initiate therapy at 4 mg/day, as a single dose or 2 divided doses. For patients who respond inadequately following 8 to 12 wk of treatment, the dosage may be increased to 8 mg daily (max, 8 mg/day).
May decrease rosiglitazone AUC; changes in diabetes treatment may be needed when the CYP2C8 inducer is started or stopped. Clinical and laboratory monitoring is warranted. Adjust the rosiglitazone dose as needed.