Intramuscular Susceptible Gram-negative and staphylococcal infections
Adult: 3 mg/kg daily in 2-3 divided doses. May also be given as IV infusion, if needed.
Renal impairment: May need to adjust maintenance doses and/or dosing intervals.
Topical/Cutaneous Pyoderma Adult: As 0.1% cream: Apply onto the affected area(s) bid.
Plasma levels increased by indometacin. Antihistamines (H1-receptor blocker) may mask early signs of ototoxicity. Incompatible with some β-lactam antibiotics.
Potentially Fatal: Potentiates nephrotoxicity produced by other nephrotoxic drugs including other aminoglycosides, vancomycin and some cephalosporins. Potentiates ototoxicity produced by other aminoglycosides, ethacrynic acid. Ototoxicity potentiated by furosemide.