Diagnosis of Primary Hyperaldosteronism
Adults: PO 400 mg/day for 4 days (short test) or 3 to 4 wk (long test).
Maintenance Therapy for Hyperaldosteronism
Adults: PO 100 to 400 mg daily in single or divided doses.
Adults: PO 25 to 200 mg/day in single or divided doses.
Children: PO 3.3 mg/kg/day in single or divided doses.
Adults: PO 50 to 100 mg/day in single or divided doses.
Children: PO 1 to 2 mg/kg twice daily.
Adults: PO 25 to 100 mg/day when oral potassium or other potassium-sparing regimens are inappropriate.
Competitively inhibits aldosterone in distal tubules, resulting in increased excretion of sodium and water and decreased excretion of potassium.
Anuria; acute renal insufficiency; impaired renal excretory function; hyperkalemia.
CNS: Drowsiness; lethargy; headache; mental confusion; ataxia.
DERM: Maculopapular or erythematous cutaneous eruptions; urticaria.
GI: Cramping; diarrhea; gastric bleeding; gastric ulceration; gastritis; vomiting.
GU: Inability to achieve or maintain erection.
HEPA: Hyperchloremic metabolic acidosis in decompensated hepatic cirrhosis.
OTHER: Gynecomastia; irregular menses or amenorrhea; postmenopausal bleeding; hirsutism; deepening of voice; drug fever; carcinoma of breast.
May result in severely elevated serum potassium levels.
May decrease digoxin clearance, resulting in increased serum digoxin levels and toxicity; may attenuate inotropic action of digoxin.
May decrease therapeutic response to mitotane.
May severely increase serum potassium levels, possibly resulting in cardiac arrhythmias or cardiac arrest. Do not take with potassium preparations.
May result in decreased diuretic effect.
Therapeutic Classification: diuretics, potassium-sparing diuretics
Absorption: >90% absorbed.
Distribution: Crosses the placenta; enters breast milk.
Protein Binding: >90%.
Metabolism/Excretion: Converted by the liver to its active diuretic compound (canrenone).
Half-life: 78–84 min (spironolactone); 13–24 hr (canrenone).
Duration vary in multiple dose
Copyright ©Nims Drugs2015. All rights reserved.
Powered by : web creation Nepal