PO (Adults): 0.4 mg once daily after a meal; may be increased after 2–4 wk to 0.8 mg/day.
Selectively blocks alpha1 -adrenergic receptors causing relaxation of prostate smooth muscle resulting in an increase in urinary flow rate and a reduction in symptoms of benign prostatic hypertrophy.
Use Cautiously in:
CNS: dizziness, headache.
CV: orthostatic hypotension .
GU: retrograde/diminished ejaculation .
Therapeutic Classification: n/a
Pharmacologic Classification: peripherally acting antiadrenergics
Absorption: Slowly absorbed after oral administration.
Distribution: Widely distributed.
Protein Binding: 94–99%.
Metabolism/Excretion: Extensively metabolized by the liver; <10% excreted unchanged in urine.
Half-life: 14 hr.
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