Male Hypogonadism (replacement therapy)
Delayed Male Puberty
Palliative Management of Breast Cancer (in postmenopausal women)
Use Cautiously in:
EENT: deepening of voice.
CV: edema .
GI: cholestatic jaundice , drug-induced hepatitis, liver function test elevation, nausea, vomiting .
GU: women-: change in libido, clitoral enlargement , menstrual irregularities.
men-: erectile dysfunction, priapism , prostatic enlargement.
men-: gynecomastia, oligospermia .
F and E: hypercalcemia , hyperkalemia, hyperphosphatemia .
Derm: male pattern baldness .
Local: pain at injection site.
Therapeutic Classification: hormones
Pharmacologic Classification: androgens
Absorption: Well absorbed from IM sites; absorbed slowly.
Distribution: Crosses the placenta.
Protein Binding: 98%.
Metabolism/Excretion: Metabolized by the liver; 90% eliminated in urine as metabolites.
Half-life: 10–100 min.
†Response is highly variable among individuals; may take months
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