Inhaln (Adults): 18 mcg once daily.
Inhibits smooth muscle receptors, leading to bronchodilation.
Hypersensitivity to ipratropium or tiotropium.
Resp: paradoxical bronchospasm.
CV: increases heart rate.
GI: dry mouth, constipation.
GU: urinary difficulty, urinary retention .
Misc: hypersensitivity reactions including angioedema.
None well documented.
Therapeutic Classification: bronchodilators
Pharmacologic Classification: anticholinergics
Absorption: 19.5% absorbed following inhalation.
Distribution: Extensive tissue distribution; due to route of administration increase concentrations occur in lung.
Metabolism/Excretion: 74% excreted unchanged in urine; 25% of absorbed drug is metabolized.
Half-life: 5–6 days.
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