• IV: Treatment of potentially life-threatening infections when less toxic anti-infectives are contraindicated. Particularly useful in staphylococcal infections, including. › Endocarditis.
› Soft-tissue infections in patients who have allergies to penicillin or its derivatives or when sensitivity testing demonstrates resistance to methicillin.
• PO: Treatment of staphylococcal enterocolitis or pseudomembranous colitis due to Clostridium difficile.
• IV: Part of endocarditis prophylaxis in high-risk patients who are allergic to penicillin.
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• IV (Adults and Adolescents): 1-g single dose 1-hr preprocedure.
• IV (Children): 20-mg/kg single dose 1-hr preprocedure.
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• PO (Adults): 125–500 mg q 6 hr.
• PO (Children): 40 mg/kg/day divided q 6 hr for 7–10 days( not to exceed 2 g/day) .
• IV (Adults): An initial loading dose of 750 mg–1 g (not less than 15 mg/kg); serum level monitoring is optimal for choosing maintenance dosage in patients with renal impairment; these guidelines may be helpful. CCr 50–80 ml/min — 1 g q 1–3 days; CCr 10–50 ml/min —1 g q 3–7 days; CCr <10 ml/min —1 g q 7–14 days.
• May cause additive ototoxicity and nephrotoxicity with other ototoxic and nephrotoxic drugs (aspirin, aminoglycosides, cyclosporine, cisplatin, loop diuretics).
• May enhance neuromuscular blockade from nondepolarizing neuromuscular blocking agents.
• Increased risk of histamine flush when used with general anesthetics in children.