Initial dose: Initial dose for inhalation 0.08 to 0.1 mg/kg. Reduce initial dose by 15% (0.06 to 0.85 mg/kg) if inhalation agents are already in use. If intubation is performed using succinylcholine, reduce initial dose to 0.04 to 0.06 mg/kg with inhalation anesthesia and 0.05 to 0.06 mg/kg with balanced anesthesia
Maintenance: IV bolus 0.01 to 0.015 mg/kg within 25 to 40 min of initial dose, then q 12 to 15 min.
IV infusion: 1 mcg/kg/min initially beginning 20 to 40 min after IV bolus. Titrate to desired clinical response.
Children 1 to 10 yr of age:IV Slightly higher initial doses and more frequent supplementation.
Infants 7 wk to 1 yr of age:IV Slightly lower doses and 1.5 times less frequent.
Distribution: About 60% to 80% bound to plasma proteins. Distribution t½ is about 4 min. Vd is 300 to 400 mL/kg.
Metabolism: One metabolite, 3-desacetyl vecuronium, has been recovered in urine of some patients in quantities that account for up to 10% of an injected dose. 3-desacetyl vecuronium also has been recovered by T-tube in some patients accounting for up to 25% of the injected dose.
Excretion: The t½ is 65 to 75 min. In late pregnancy, the t½ is about 35 to 40 min. Systemic rate of clearance is about 3 to 4.5 mL/min/kg. Urine recovery varies from 3% to 35% within 42 h.