CV: Hypertension; hypotension; MI. CNS: Autonomic and peripheral neuropathy; headache. DERM: Alopecia; rash GI: Mucositis; abdominal cramps; diarrhea; anorexia; intestinal necrosis or perforation; constipation that can lead to upper colon impaction; paralytic ileus; weight loss. GU: Amenorrhea; polyuria; dysuria; urinary retention because of bladder atony; azoospermia. HEMA: Bone marrow suppression; nadir less than 7 days. MUSC: Acute bone or jaw pain. RESP: Acute shortness of breath; severe bronchospasm. SPEC SENSE: Optic atrophy with blindness; transient cortical blindness; ptosis; diplopia; photophobia. OTHER: Fever.