Lowers blood glucose by inhibiting the enzyme alpha-glucosidase in the GI tract. Delays and reduces glucose absorption. Therapeutic Effects:
Lowering of blood glucose in diabetic patients, especially postprandial hyperglycemia.
Thiazide diuretics and loop diuretics, corticosteroids, phenothiazines, thyroid preparations, estrogens (conjugated), progestins, hormonal contraceptives, phenytoin, niacin, sympathomimetics, calcium channel blockers, and isoniazid may ↑ glucose levels in diabetic patients and lead to ↓ control of blood glucose.
Effects are↓ by intestinal adsorbents, including activated charcoal and digestive enzyme preparations (amylase, pancreatin); avoid concurrent use.
effects of sulfonylurea hypoglycemic agents.
May↓ absorption of digoxin; may require dosage adjustment. Drug-Natural Products: Glucosamine may worsen blood glucose control.
Chromium and coenzyme Q-10 may↑ hypoglycemic effects